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pentobarbital will decrease the extent or effect of exemestane by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. For people receiving exemestane using a potent CYP3A4 inducer the encouraged dose of exemestane is 50 mg each day following a food.Steer clear of concomitant utilization of tucatinib with CYP3A substrates, ex